Originalarbeiten 2006:

• Wicovsky, A., Muller, N., Daryab, N., Marienfeld, R., Kneitz, C., Kavuri, S., Leverkus, M., Baumann, B. and Wajant H. (2006). Sustained JNK activation in response to TNF is mediated by caspases in a cell type-specific manner.
  J. Biol. Chem., [Epub ahead of print].
• Watermann, I., Gerspach, J., Lehne, M., Seufert, J., Schneider, B., Pfizenmaier, K., Wajant, H. (2006). Activation of CD95L fusion protein prodrugs by tumor-associated proteases.
  Cell Death Differ., [Epub ahead of print].
• Begue, B., Wajant, H., Bambou, J.C., Dubuquoy, L., Siegmund, D., Beaulieu, J.-F., Canioni, D., Berrebi, D., Brousse, N., Desreumaux, P., Schmitz, J., Lentze, M.J., Goulet, O., Cerf-Bensussan, N. and Ruemmele F.M. (2006). Implication of TNF-related apoptosis inducing ligand (TRAIL) in inflammatory intestinal epithelial lesions.
  Gastroenterology, 130: 1962-1974.
• Assohou-Luty, C., Gerspach, J., Siegmund, D., Müller, N., Huard, B., Tiegs, G., Pfizenmaier, K., Wajant, H. (2006). A CD40-CD95L fusion protein interferes with CD40L-induced pro-survival signalling and allows membrane CD40L-restricted activation of CD95.
  J. Mol. Med., 84: 785-797.
• Trauzold, A., Siegmund, D., Schniewind, B., Sipos, B., Egberts, J., Zorenkov, D., Emme, E., Röder, C., Kalthoff, H., and Wajant, H. (2006). TRAIL promotes metastasis of human pancreatic ductal adenocarcinoma.
  Oncogene, in press.
• Gerspach, J.,  Nemeth, J., Munkel, S., Wajant, H., and Pfizenmaier, K. (2006). Target-selective activation of a TNF prodrug by urokinase-type plasminogen activator (uPA) mediated proteolytic processing at the cell surface.
  Cancer Immunol Immunother., 55: 1590-1600.
• Gerspach, J., Müller, D., Münkel, S., Selchow, O., Nemeth, J., Noack, M., Menrad, A., Wajant, H. and Pfizenmaier, K. (2006). Restoration of membrane TNF like activity by cell surface targeting and metalloproteinase-mediated processing of a TNF prodrug.
  Cell Death Differ., 13: 273-284.

Übersichtsarbeiten 2006:

• Wajant, H. TNF receptor / Fas signaling. In „Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine“ Springer Verlag, Heidelberg, in press.
• Wajant, H. (2006). CD95L/FasL and TRAIL in tumour surveillance and cancer therapy.
  Cancer Treat Res. 130:141-165.

Originalarbeiten 2005:

• Wicovsky, A., Siegmund, D. and Wajant H. (2005). Interferons induce proteolytic degradation of TRAILR4.
  Biochem. Biophys. Res. Commun., 337: 184-190.
• Siegmund, D., Wicovsky, A., Schmitz, I., Schulze-Osthoff, K-S., Kreuz, S., Leverkus, M., Dittrich-Breiholz, O., Kracht, M. and Wajant, H. (2005). Death receptor-induced signaling pathways are differentially regulated by interferon-gamma upstream of caspase-8 processing.
  Mol. Cell. Biol., 25: 6363-6379.
• Henkler, F., Behrle, E., Dennehy, KM., Wicovsky, A.,  Peters,N., Warnke,C., Pfizenmaier, K., and  Wajant, H. (2005). The extracellular domains of FasL and Fas are sufficient for the formation of supramolecular FasL-Fas clusters of high stability.
  J. Cell Biol.,168,1087-1098.
• Trauzold, A., Roder, C., Sipos, B., Karsten, K., Arlt, A., Jiang, P., Martin-Subero, J. I., Siegmund, D., Muerkoster,S., Pagerols-Raluy, L.,Siebert, H., Wajant, H., and Kalthoff, H. (2005). CD95 and TRAF2 promote invasiveness of pancreatic cancer cells.
  Faseb J.,19, 620-622.

Übersichtsarbeiten 2005:

• Wajant, H., Gerspach, J., and  Pfizenmaier, K. (2005).
  Tumor therapeutics by design: targeting and activation of death receptors.
  Cytokine Growth Factor Rev.,16,55-76.

Originalarbeiten 2004:

• Chaneva, S., Schneider, G., Siegmund, D., Wajant, H., Mages,J., and Hacker, G. (2004).
  Enhanced basal AP-1 activity and de-regulation of numerous genes in T cells transgenic for a dominant interfering mutant of FADD/MORT1.
  Eur. J. Immunol.,34, 3006-3015.
• Kreuz, S., Siegmund, D., Rumpf,J.J., Samel, D., Leverkus, M., Janssen, O., Hacker, G., Dittrich-Breiholz, O., Kracht, M., Scheurich.,P., and Wajant, H. (2004).
  NFkappaB activation by Fas is mediated through FADD, caspase-8, and P and is inhibited by FLIP.
  J. Cell Biol.,166, 369-380.
• Fotin-Mleczek, M., Henkler, F., Hausser, A., Glauner, H., Samel, D., Graness, A., Scheurich, P., Mauri, D. & Wajant, H. (2004).
  Tumor necrosis factor receptor-associated factor (TRAF) 1 regulates CD40-induced TRAF2-mediated NF-kappaB activation.
  J.Biol. Chem. 279, 677-85.

Übersichtsarbeiten 2004:

• Wajant, H. (2004). TRAI4 and NFkappaB signaling-a complex relationship.
  Vitam. Horm., 67, 101-132.
• Wajant, H., Scheurich, P. (2004). Analogies betwen Drosophila and mamalian TRAF pathways.
  Prog. Mol. Subcell Bio., 34, 46-72.

Originalarbeiten 2003:

• Henkler, F., Baumann, B., Fotin-Mleczek, M., Weingärtner, M., Schwenzer, R., Peters, N., Wirth, T., Scheurich, P., Schmid, JA. and Wajant, H. (2003).Caspase-mediated cleavage converts TRAF1 from a selective modulator of TNF receptor signaling to a general inhibitor of NF-B activation
  J. Biol. Chem., (epub ahead of print).
• Buhler H., Effenberger F., Forster S., Roos J., and Wajant H. (2003).Substrate Specificity of Mutants of the Hydroxynitrile Lyase from Manihot esculenta.
  ChemBiochem., 4 211-216.

Übersichtsarbeiten 2003:

• Wajant H., Pfizenmaier, K., and Scheurich P. (2003). Tumor Necrosis Factor.
  Cell Death and Differ., 10 45-65.
• Wajant. H., Pfizenmaier, K., and Scheurich, P. ( 2003). Non-apoptotic Fas signaling
  Cytokine and Growth Factor Rev., 14 53-66.

• Siegmund, D., Pfizenmaier, K., Vornlocher, H.-P., and Wajant, H. (2002). Selective inhibition of FLICE-like inhibitory protein (FLIP) expression with shortdouble-stranded RNA oligonucleotides is sufficient to sensitise tumor cells for TRAIL-induced apoptosis.
  Mol. Med., 8 725-732.
• Baumann, B., Bohnenstengel, F., Siegmund, D., Wajant, H., Weber, C., Herr, I., Debatin, K.-M., Proksch, P. and Wirth, T. (2002). Rocaglamide derivatives are potent inhibitors of NF-B activation in T-cells.
  J. Biol. Chem., 277 44791-44800.
• Lauble, H., Miehlich, B., Förster, S., Wajant, H., and Effenberger, F. (2002). Crystal structure of hydroxynitrile lyase from Sorghum bicolor in complex with inhibitor benzoic acid: a novel cyanogenic enzyme.
  Biochemistry, 41 12043-12050.
• Glauner, H., Siegmund, D., Motejadded, H., Scheurich, P., Henkler, F., Janssen, O., and Wajant, H. (2002). Intracellular localization and transcriptional regulation of tumor necrosis factor (TNF) receptor-associated factor 4 (TRAF4).
  Eur. J. Biochem., 269 4819-4829.
• Weingärtner, M., Siegmund, D., Schlecht, U., Fotin-Mleczek, M., Scheurich, P., and Wajant, H. (2002). Endogenous membrane TNF is a potent amplifier of TNF-R1-mediated apoptosis.
  J. Biol. Chem., 277 34853-34859.
• Fotin-Mleczek, M., Henkler, F., Samel D., Reichwein, M., Parmryd, I., Scheurich, P., Schmid, J.A., and Wajant, H. (2002). The combination of TNF-R2-induced TRAF2-depletion and delayed TNF-R1-dependent activation of caspase-8 is the molecular basis of the apoptotic crosstalk of TNF-R1 and TNF-R2.
  J. Cell Sci., 115 2757-2770.
• Oßwald, S., Wajant, H. and Effenberger, F. (2002). Characterization and Synthetic Applications of Recombinant AtNIT1 from Arabidopsis thaliana.
  Eur. J. Biochem., 269 680-687.
• Lauble, H., Miehlich, B., Förster, S., Kobler, C., Wajant, H., and Effenberger, F. (2002). Structure determinants of substrate specificity of hydroxynitrile lyase from Manihot esculenta.
  Protein Sci., 11 65-71.

Übersichtsarbeiten 2002:

• Wajant, H., Pfizenmaier, K., and Scheurich, P. (2002). TNF-related apoptosis inducing ligand (TRAIL) and its receptors in tumor surveillance and cancer therapy.
  Apoptosis, 7 449-459.
• Wajant, H. (2002). The Fas signaling pathway: More than a paradigm of death receptor-induced apoptosis.
  Science, 296 1635-1636. Wajant, H. (2002). Fas signaling pathway. Science, Signal Transduction Knowledge Environment.

Originalarbeiten 2001:

• Siegmund, D., Hausser, A., Peters, N., Scheurich, P., and Wajant, H. (2001). Tumor Necrosis Factor and phorbolester induce TRAIL under critical involvement of NEMO/IKK.
  J. Biol. Chem., 276 43708-43712.
• Siegmund, D., Mauri, D., Peters, N., Juo, P., Thome, M., Reichwein, M., Blenis, J., Scheurich, P., Tschopp, J., and Wajant, H. (2001). FADD and Caspase-8 mediate up-regulation of c-fos by FasL and TRAIL via a FLIP-regulated pathway.
  J. Biol. Chem., 276 32585-32590.
• Wajant, H., Moosmayer, D., Wüest, T., Bartke, T., Gerlach, E., Peters, N., Scheurich, P., and Pfizenmaier, K. (2001). Differential activation requirements of TRAIL-R1 and –2 allows surface antigen-directed activation of TRAIL-R2 by a soluble TRAIL derivate.
  EMBO J., 18 3034-3043.
• Kreuz, S., Siegmund, D., Scheurich, P., and Wajant, H. (2001). NF-B inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor Signaling.
  J. Biol. Chem., 276 43708-43712.
• Lauble, H., Miehlich, B., Förster, S., Wajant, H., and Effenberger, F. (2001). Mechanistic aspects of cyanogenesis from active-site mutant Ser80Ala of hydroxynitrile lyase from Manihot esculenta in complex with acetone cyanohydrin.
  J. Biol. Chem., 276 32585-32590.
• Bartke, T., Siegmund, D., Peters, N., Reichwein, M., Henkler, F., Scheurich, P., and Wajant, H. (2001). p53 upregulates cFLIP, inhibits transcription of NF-B-regulated genes and induces caspase-8-independent cell death in DLD-1 cells.
  Oncogene, 20 4101-4106.
• Lauble, H., Förster, S., Miehlich, B., Wajant, H., and Effenberger, F. (2001). Crystall structure of hydroxynitrile lyase from Manihot esculenta in complex with substrates acetone and chloroacetone: Implication for the molecular mechanism of cyanogenesis.
  Acta Cryst., D57 194-200.
• Preiss, A., Johannes, B., Peters, N., Nagel, A. C., Maier, D., and Wajant, H. (2001). Dynamic expression of Drosophila TRAF1 during embryogenesis and larval development.
  Mol. Cell. Biol., 21 3964-3973.

Übersichtsarbeiten 2001:

• Wajant, H., Henkler, F., and Scheurich, P. (2001). The TNF receptor-associated factor (TRAF) family: Scaffold molecules for cytokine receptors, kinases and their regulators.
  Cell. Signal., 13 389-400.
• Wajant, H. and Pfizenmaier, K. (2001). Vom Tumornekrosefaktor zum TRAIL-AMAIZe: Antitumoral wirksame Zytokine der zweiten Generation.
  Onkologie, 24 6-10.
• Wajant, H. and Scheurich, P. (2001). Tumor Necrosis Factor Receptor-associated factor (TRAF) 2 and its role in TNF Signaling.
  Int. J. Biochem. Cell Bio., 33 19-32.

Originalarbeiten 2000:

• Engels, I. H., Stepczynska, A., Stroh, C., Berg, C., Schwenzer, R., Wajant, H., Jänicke, R. U., Porter, A. G., Belka, C., Gregor, M., Schulze-Osthoff, K., and Wesselborg, S. (2000). Caspase-8/FLICE functions as an executioner caspase in anticancer drug-induced apoptosis.
  Oncogene, 19 4563-4573.
• Mühlenbeck, F., Schneider, P., Bodmer, J.-L., Schwenzer, R., Hausser, A., Schubert, G., Scheurich, P., Moosmayer, D., Tschopp, J., and Wajant, H. (2000). TRAIL-R1 and TRAIL-R2 have distinct cross-linking requirements for initiation of apoptosis and are non-redundant in JNK activation.
  J. Biol. Chem., 275 32208-32213.
• Wajant, H., Haas, E., Schwenzer, R., Mühlenbeck, F., Sebastian Kreuz, Schubert, G., Smith, C., and Scheurich, P. (2000). Inhibition of death receptor-mediated gene induction by a cycloheximide-sensitive factor occurs at the level or upstream of FADD.
  J. Biol. Chem., 275 24357-24366.
• Irmler, M., Martinon, F., Holler, N., Steiner, V., Ruegg, C., Wajant, H. and Tschopp, J. (2000). Activation of a pro-apoptotic amplification loop through inhibition of NF-kappa B-dependent survival signals by caspase-mediated inactivation of TRAF1 and RIP.
  FEBS Lett., 468 129-33.

Übersichtsarbeiten 2000:

• Schwenzer, R., Zimmermann, G., Fotin, M., Wajant, H., and Grell, M. (2000). No RISC, no fun: assembly of receptor-induced signalling complexes in the tumor necrosis factor system.
  Eur. Cytokine Netw., 11 519-520.
• Effenberger, F., Förster, S., and Wajant, H. (2000). Oxynitrilases in stereoselective catalysis.
  Curr. Opin. Biotechnol., 11 532-539.

Originalarbeiten 1999:

• Schwenzer, R., Siemienski, K., Liptay, S., Schubert, G., Peters, N., Scheurich, P., Schmid, R., and Wajant, H. (1999). The human TNF receptor associated factor (TRAF) 1 gene is upregulated by cytokines of the TNF ligand family and modulates TNF-induced activation of NF-B and JNK.
  J. Biol. Chem., 274 19368-19374.
• Haas, E., Grell, M., Wajant, H., and Scheurich, P. (1999). Continous autotropic signaling by membrane expressed tumor necrosis factor.
  J. Biol. Chem., 274 18107-18112.
• Lauble, H., Decanniere, K., Wajant, H., Foerster, S., Effenberger, F. (1999). Crystallization and preliminary X-ray diffraction analysis of hydroxynitrile lyase from cassava (Manihot esculenta).
  Acta Cryst., D55 904-906.
• Grell, M., Zimmermann, G., Gottfried, E., Chen C.-M., Grünwald, U., Huang, D.C.S., Lee Y-H.W. Lee, Dürkop, H., Engelmann, H., Scheurich, P., Wajant, H.*, and Strasser, A*. (1999). *share senior authorship. Induction of cell death by tumor necrosis factor (TNF) receptor 2, CD40 and CD30 - a role for TNF-R1 activation by endogenous membrane-anchored TNF.
  EMBO J., 18 3034-3043.
• Schneider, P., Schwenzer, R., Mühlenbeck, F., Haas, E., Tschopp, J., and Wajant, H. (1999). TWEAK induces cell death via endogenous TNF and TNF-R1.
  Eur. J. Immunol., 29 1785-1792.

Übersichtsarbeiten 1999:

• Wajant, H., Grell, M., and Scheurich, P (1999). TNF receptor associated factors (TRAF) in cytokine signaling.
  Cytokine and Growth Factor Rev., 10 15-26.

Originalarbeiten 1998:

• Trummler, K., Roos, J., Schwaneberg, U., Emerich, U., Effenberger, F., Förster, S., Pfizenmaier, K., and Wajant, H. (1998). Expression of the Zn2+-containing hydroxynitrile lyase from flax (Linum usitatissimum) in Pichia pastoris - utilization of the recombinant enzyme for enzymatic analysis and site-directed mutagenesis.
  Plant Science, 139 19-27.
• Mühlenbeck, F., Haas, E., Schwenzer, R., Schubert, G., Grell, M., Smith, C., Scheurich, P., and Wajant, H. (1998). TRAIL activates c-Jun N-terminal kinase (JNK) via caspase-dependent and caspase-independent pathways.
  J. Biol. Chem., 273 33091-33098.
• Johannes, F.J., Horn, J., Link, G., Haas, E., Siemienski, K., Wajant, H., and Pfizenmaier, K. (1998). Protein Kinase C µ downregulates TNF induced apoptosis via enhancement of NF-B dependent protective genes.
  Eur. J. Biochem., 257 47-54.
• Wajant, H., Mühlenbeck, F., and Scheurich, P. (1998). Identification of a TRAF gene in Caenorhabditis elegans.
  J. Mol. Evol., 47 656-662.
• Weiss, T., Grell, M., Siemienski, K., Dürkop, H., Pfizenmaier, K., Scheurich, P., and Wajant, H. (1998). TNFR80-dependent enhancement of TNFR60-induced cell death is mediated by TRAF2 and is specific for TNFR60.
  J. Immunol., 161 3136-3142.
• Grell, M., Becke, F. M., Wajant, H., Männel, D. N., and Scheurich, P. (1998). Tumor necrosis factor (TNF) receptor type 2 mediates thymocyte proliferation independently of TNF receptor type 1.
  Eur. J. Immunol., 28 257-263.
• Grell, M., Wajant, H., Zimmermann, G., and Scheurich, P. (1998). The typ I receptor (CD120a) is the high affinity receptor for soluble tumor necrosis factor. Proc.
  Natl. Acad. Sci. USA, 95 570-575.
• Wajant, H., Johannes, F.-J., Haas, E., Siemienski, K., Schubert, G., Weiss, T., Grell, M., and Scheurich, P. (1998). A dominant negative mutant of FADD interferes with TNFR60-, Fas/Apo1- and TRAIL-R/Apo2-mediated cell death but not with NF-B activation and gene induction.
  Curr. Biol., 8 113-116.

Übersichtsarbeiten 1998:

• Scheurich, P., Pfeffer, K., and Wajant, H. (1998). Tumor necrosis factors in 1998.
  Cytokine and Growth Factor Rev., 9 297-302.

Originalarbeiten 1997:

• Weiss, T., Grell, M., Hessabi, B., Bourteele, S., Müller, G., Scheurich, P., and Wajant, H. (1997). Enhancement of TNF receptor p-60 mediated cytotoxicity by TNF receptor p80 - Requirement of the TNF receptor-associated factor-2 binding site.
  J. Immunol.,158 2398-2404.
• Trummler, K., and Wajant, H. (1997). Molecular cloning of acetone cyanohydrin lyase from Linum usitatissimum - Definition of a novel class of hydroxynitrile lyases.
  J. Biol. Chem., 272 4770-4774.
• Siemienski, K., Scheurich, P., and Wajant, H. (1997). Organization of the human TNF receptor associated factor (TRAF)1 gene and mapping to chromosome 9q33-34.
  Gene, 195 35-39.

Originalarbeiten 1996:

• Wajant, H., Förster, S., Sprauer, A., Effenberger, F., and Pfizenmaier, K. (1996). Enantioselective synthesis of aliphatic (S)-cyanohydrins in organic solvents using hydroxynitrile lyase from Manihot esculenta.
  Annals N. Y. Acad. Sci., 799 771-776.
• Wajant, H., and Pfizenmaier, K. (1996). Identification of potential active-site residues in the hydroxynitrile lyase from Manihot esculenta by site-directed mutagenesis.
  J. Biol. Chem., 271 25830-25834.
• Wajant, H., and Förster, S. (1996). Purification and characterization of hydroxynitrile lyase from Hevea brasiliensis.
  Plant Science, 115 25-31.
• Moosmayer, D., Wajant, H., Gerlach, E., Schmidt, M., Brocks, B., and Pfizenmaier, K. (1996). Characterization of different soluble TNF receptor (TNFR80) derivatives: positive influence of the intracellular domain on receptor/ligand interaction and TNF neutralization capacity.
  Lymphokine Cytokine Res., 16 471-477.
• Lauble, H., Knödler, S., Schindelin, H., Förster, S., Wajant, H., and Effenberger, F. (1996). Crystallographic studies and preliminary X-ray investigation of (S)-p-hydroxy-mandelonitrile lyase from Sorghum bicolor (L.).
  Acta Cryst., D52 887-889.
• Hornung, E., Wajant, H., Jeske, H., and Mundry, K.-W. (1996). Cloning of a cDNA encoding a new ribosome-inactivating protein from Beta vulgaris vulgaris (mangold).
  Gene, 170 233-236.
• Förster, S., Roos, J., Effenberger, F., Wajant, H., and Sprauer, A. (1996). The first recombinant hydroxynitrile lyase and its application in the synthesis of (S)-cyanohydrins.
  Angew. Chem. Int. Ed. Engl., 35 437-439.

Übersichtsarbeiten 1996:

• Wajant, H., and Effenberger, F. (1996) Hydroxynitrile lyases of higher plants.
  Biol. Chem., 377 611-617.
• Pfizenmaier, K., Wajant, H., and Grell, M. (1996). Tumor necrosis factors in 1996.
  Cytokine and Growth Factor Rev., 7 271-277.

Originalarbeiten 1995:

• Wajant, H., Förster, S., Selmar, D., Effenberger, F., and Pfizenmaier, K. (1995). Purification and characterization of a novel (R)-mandelonitrile lyase from the fern Phlebodium aureum.
  Plant Physiol., 109 1231-1238.
• Wajant, H., Förster, S., Böttinger, H., Effenberger, F., and Pfizenmaier, K. (1995). Acetone cyanohydrin lyase from Manihot esculenta (cassava) is serologically distinct from other hydroxynitrile lyases.
  Plant Science, 108 1-11.
• Grell, M., Douni, E., Wajant, H., Löhden, M., Clauss, M., Maxeiner, B., Georgpoulos, S., Lesslauer, W., Kollias, G., Pfizenmaier, K., and Scheurich, P. (1995). The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor.
  Cell, 83 793-802.